Inflammation and atherosclerosis: fulfilling Koch’s postulates
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چکیده
منابع مشابه
Identification of Unknown Turfgrass Pathogens: Kochs Postulates
History In 1876, a country doctor in Germany by the name of Robert Koch developed the first conclusive empirical evidence that a particular microbe causes a particular disease. Although he was working on anthrax, a deadly disease of warm-blooded animals (caused by the bacterium Bacillus anthracis), the procedures he laid out for determining the pathogenicity of a microorganism (in other words, ...
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An expanding body of evidence continues to build on the role of platelets as initial actors in the development of atherosclerotic lesions. Platelets bind to leukocytes and endothelial cells, and initiate monocyte transformation into macrophages. Platelets internalize oxidized phospholipids and promote foam cell formation. Platelets also recruit progenitor cells to the scene that are able to dif...
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The deleterious effects of high low-density lipoprotein (LDL) cholesterol levels on atherosclerosis has been known for almost a century,1 yet plasma cholesterol continues to be a challenge for clinicians in the treatment and prevention of cardiovascular disease.2,3 Atherogenesis involves uptake of cholesterol in the vascular wall, followed by inflammatory activation and growth of vascular smoot...
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Only half of coronary artery disease, 1,2 and half of carotid plaque measured by ultrasound,3 can be explained by the usual risk factors: age, sex, hypertension, hyperlipidemia, smoking, and diabetes. It is likely that much of unexplained atherosclerosis is genetic: a Swedish twin study showed that myocardial infarction below age 46 is almost entirely heritable.4 This suggests that few environm...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Cardiovascular Disease
سال: 2017
ISSN: 1753-9447,1753-9455
DOI: 10.1177/1753944717744740